Learning Rules for Spike Timing-Dependent Plasticity Depend on Dendritic Synapse Location
نویسندگان
چکیده
منابع مشابه
Learning rules for spike timing-dependent plasticity depend on dendritic synapse location.
Previous studies focusing on the temporal rules governing changes in synaptic strength during spike timing-dependent synaptic plasticity (STDP) have paid little attention to the fact that synaptic inputs are distributed across complex dendritic trees. During STDP, propagation of action potentials (APs) back to the site of synaptic input is thought to trigger plasticity. However, in pyramidal ne...
متن کاملDendritic Synapse Location and Neocortical Spike-Timing-Dependent Plasticity
While it has been appreciated for decades that synapse location in the dendritic tree has a powerful influence on signal processing in neurons, the role of dendritic synapse location on the induction of long-term synaptic plasticity has only recently been explored. Here, we review recent work revealing how learning rules for spike-timing-dependent plasticity (STDP) in cortical neurons vary with...
متن کاملSpike-Timing-Dependent Plasticity, Learning Rules
Biological phenomenon. Spike-timing dependent plasticity (STDP) in its narrow sense refers to the change in the synaptic strength as a result of electrically eliciting pairs of action potentials (‘spikes’) with a fixed time difference between the preand post-synaptic action potentials (Markram et al., 1997; Bi and Poo, 1998; Sjostrom et al., 2001). STDP is typically observed for synapses betwee...
متن کاملSpike timing dependent plasticity: mechanisms, significance, and controversies
Long-term modification of synaptic strength is one of the basic mechanisms of memory formation and activity-dependent refinement of neural circuits. This idea was purposed by Hebb to provide a basis for the formation of a cell assembly. Repetitive correlated activity of pre-synaptic and post-synaptic neurons can induce long-lasting synaptic strength modification, the direction and extent of whi...
متن کاملSpike timing dependent plasticity: mechanisms, significance, and controversies
Long-term modification of synaptic strength is one of the basic mechanisms of memory formation and activity-dependent refinement of neural circuits. This idea was purposed by Hebb to provide a basis for the formation of a cell assembly. Repetitive correlated activity of pre-synaptic and post-synaptic neurons can induce long-lasting synaptic strength modification, the direction and extent of whi...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2006
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.2650-06.2006